Clinical effect of shenbing mistura combined with glucocorticoid on recurrent nephrotic syndrome in children and levels of interleukin-6 and tumor necrosis factor-alpha in blood and urine / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 892-895, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-331957
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Shenbing Mistura (SM) combined with glucocorticoid on recurrent nephrotic syndrome (RNS) in children and levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in blood and urine.</p><p><b>METHODS</b>The treatment group was treated with SM plus glucocorticoid, the control group with glucocorticoid alone, and a healthy control group was adopted, 30 cases in each group. The clinical effect and recurrence rate were observed, and levels of IL-6 and TNF-alpha in blood and urine were determined before treatment and at the 4th, 8th, 12th week after treatment.</p><p><b>RESULTS</b>Significant difference of IL-6 and TNF-alpha levels in blood and urine was found in either the pre- and post- treatment auto-control of both the treatment group and control group, or in the inter-group comparison of them (P < 0.01); clinical effect also showed remarkable difference between the two groups (P < 0.01). Furthermore, the recurrence rate of the treatment group was lower than that of the control group showed by a 18-month follow-up (P < 0.01).</p><p><b>CONCLUSION</b>SM combined with glucocorticoid could significantly reduce the recurrence rate and elevate the clinical effect in children with RNS, it could also lower the levels of IL-6 and TNF-alpha in patients' blood and urine.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Recurrence
/
Urine
/
Blood
/
Prednisone
/
Drugs, Chinese Herbal
/
Follow-Up Studies
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
/
Treatment Outcome
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2006
Type:
Article
Similar
MEDLINE
...
LILACS
LIS