Blood levels of true insulin and immunoreactive insulin in evaluating beta-cell function with arginine stimulation test / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 255-259, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-332162
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the difference between serum true insulin (TI) and immunoreactive insulin (IRI) in evaluating islet beta-cell function and insulin resistance.</p><p><b>METHODS</b>The arginine stimulation test was performed in 141 individuals, including 35 with normal glucose tolerance (NGT) and 106 with type 2 diabetes (T2DM). Plasma glucose (PG), TI, IRI and proinsulin (PI) levels were measured; the incremental value of TI/PG, (TI+PI)/PG and IRI/PG (delta TI/PG, delta(TI+PI)/PG and deltaIRI/PG) and the area under curve of TI/PG, (TI+PI)/PG and IRI/PG (AUC [TI/PG], AUC[(TI+PI)/PG] and AUC [IRI/PG]) after arginine stimulation were calculated to evaluate beta-cell function.</p><p><b>RESULT</b>There were positive correlations of delta TI/PG with delta (TI+PI)/PG and delta IRI/PG in both NGT and T2DM patients (r=0.68 - 0.99, P<0.01). The similar correlations of AUC [TI/PG] with AUC [(TI+PI)/PG] and AUC [IRI/PG] were also shown (r=0.62 - 0.99, P<0.01). delta TI/PG was correlated with AUC [TI/PG] in two groups (NGT r=0.96, T2DM r=0.82, P<0.01). HOMA-IRTI, HOMA-IR(TI+PI) and HOMA-IRIRI in T2DM were higher than those in NGT (P<0.01). After arginine stimulation T2DM subjects mainly presented insulin resistance and decreased insulin secretion.</p><p><b>CONCLUSION</b>The determination of TI may be more accurate than IRI in evaluating beta-cell function and insulin resistance.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Arginine
/
Physiology
/
Proinsulin
/
Blood
/
Blood Glucose
/
Insulin Resistance
/
Diabetes Mellitus, Type 2
/
Allergy and Immunology
/
Insulin-Secreting Cells
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2006
Type:
Article
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