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Karyotype analysis of 283 cases of myelodysplastic syndrome / 浙江大学学报·医学版
Article in Chinese | WPRIM | ID: wpr-332183
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the implication of karyotype analysis in diagnosis and prognosis of myelodysplastic syndrome (MDS).</p><p><b>METHODS</b>The chromosomes were prepared with direct method, brief culture of cells and R-banding techniques, and then the karyotypic analysis was performed.</p><p><b>RESULT</b>Seventy-seven out of 283 patients (27.21%) had karyotypic abnormalities, including the numeral abnormalities of chromosomes and structural alterations. The most common chromosomal aberrations were +8, -20/20q-, -Y, translocation, -7/7q-, +9, -5/5q-. The rate of abnormal karyotype in refractory anemia with erythroblasts (RAEB) and refractory anemia erythroblasts-transformation (RAEB-t) was much higher than in refractory anemia (RA). Patients with abnormal karyotype or higher IPSS scores had a higher risk of transformation into acute leukemia than patients with normal karyotype or lower IPSS scores (P<0.05).</p><p><b>CONCLUSION</b>MDS is a highly heterogenous disorder and karyotype analysis is helpful for its diagnosis and prognosis estimation.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Translocation, Genetic / Myelodysplastic Syndromes / Aged, 80 and over / Chromosomes, Human, Pair 8 / Aged / Female / Humans / Male / Child Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Translocation, Genetic / Myelodysplastic Syndromes / Aged, 80 and over / Chromosomes, Human, Pair 8 / Aged / Female / Humans / Male / Child Language: Chinese Journal: Journal of Zhejiang University. Medical sciences Year: 2006 Type: Article