Alteration of methylation status of death-associated protein kinase (dapk) gene promoter in patients with acute myeloid leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1390-1394, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-332353
ABSTRACT
This study was purposed to analyze the methylation status of death-associated protein kinase (dapk) gene promoter in Chinese patients with acute myeloid leukemia (AML) and its relationship with clinical features. The methylation-specific PCR (MSP) technique was used to detect dapk promoter methylation in bone marrow samples from 112 cases of AML. The results indicated that gene dapk promoter hypermethylation was detected in 82 cases (73.2%), but not in 13 control group. There was no correlation of dapk gene hypermethylation with sex, age, WBC counts, platelet counts, hematologic parameters, chromosomal abnormalities and different subtypes of AML patients. It is concluded that dapk gene hypermethylation may be a common molecular event in AML.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Leukemia, Myeloid, Acute
/
Promoter Regions, Genetic
/
Calcium-Calmodulin-Dependent Protein Kinases
/
DNA Methylation
/
Apoptosis Regulatory Proteins
/
Death-Associated Protein Kinases
/
Genetics
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2010
Type:
Article
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