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Study on the immunogenicity of adeno-vector vaccine against H5N1 influenza A virus / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology ; (6): 97-99, 2009.
Article in Chinese | WPRIM | ID: wpr-332417
ABSTRACT
<p><b>OBJECTIVE</b>To construct adenovirus vector vaccine against H5N1 influenza virus and study on the immunogenicity.</p><p><b>METHODS</b>In this study, we amplified hemagglutinin (HA) gene sequence of H5N1 influenza virus (A/Anhui/1/2005), then constructed an adenovirus vector vaccine (Adv-HA), followed by tests in BALB/c mice for the immunogenicity with the vaccine and immunization strategies.</p><p><b>RESULTS</b>The recombinate Adv-HA vaccine could effectively induce both humoral and cellular immunity against human H5N1 influenza virus.</p><p><b>CONCLUSION</b>The Adv-HA vaccination against H5N1 influenza is a potential strategy and worthy of further investigation.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Virology / Influenza Vaccines / Random Allocation / Cell Line / Adenoviridae / Vaccination / Hemagglutinin Glycoproteins, Influenza Virus / Allergy and Immunology / Influenza, Human / Influenza A Virus, H5N1 Subtype Type of study: Controlled clinical trial Limits: Animals / Female / Humans Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Virology / Influenza Vaccines / Random Allocation / Cell Line / Adenoviridae / Vaccination / Hemagglutinin Glycoproteins, Influenza Virus / Allergy and Immunology / Influenza, Human / Influenza A Virus, H5N1 Subtype Type of study: Controlled clinical trial Limits: Animals / Female / Humans Language: Chinese Journal: Chinese Journal of Experimental and Clinical Virology Year: 2009 Type: Article