Study on the immunogenicity of adeno-vector vaccine against H5N1 influenza A virus / 中华实验和临床病毒学杂志
Chinese Journal of Experimental and Clinical Virology
;
(6): 97-99, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-332417
ABSTRACT
<p><b>OBJECTIVE</b>To construct adenovirus vector vaccine against H5N1 influenza virus and study on the immunogenicity.</p><p><b>METHODS</b>In this study, we amplified hemagglutinin (HA) gene sequence of H5N1 influenza virus (A/Anhui/1/2005), then constructed an adenovirus vector vaccine (Adv-HA), followed by tests in BALB/c mice for the immunogenicity with the vaccine and immunization strategies.</p><p><b>RESULTS</b>The recombinate Adv-HA vaccine could effectively induce both humoral and cellular immunity against human H5N1 influenza virus.</p><p><b>CONCLUSION</b>The Adv-HA vaccination against H5N1 influenza is a potential strategy and worthy of further investigation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Influenza Vaccines
/
Random Allocation
/
Cell Line
/
Adenoviridae
/
Vaccination
/
Hemagglutinin Glycoproteins, Influenza Virus
/
Allergy and Immunology
/
Influenza, Human
/
Influenza A Virus, H5N1 Subtype
Type of study:
Controlled clinical trial
Limits:
Animals
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Experimental and Clinical Virology
Year:
2009
Type:
Article
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