In vitro inhibitory mechanism of respiratory syncytial virus with solution prescription of zhidanhuayu / 中华实验和临床病毒学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effective part of solution prescription of Zhidanhuayu (ZDHY) against respiratory syncytial virus (RSV) in vitro.</p><p><b>METHODS</b>Observe the pathology of RSV to Hep-2 under the condition of different concentrations and each effective part of ZDHY.</p><p><b>RESULTS</b>The concentration limit causing celluar toxicity of ZDHY is 5.5 mg/ml. The ZDHY failed to block the absorption of RSV to Hep-2 within this concentration, and consequently the cell fell into the full pathological changes. During the concentration of 2.75-5.50 mg/ml, the ZDHY directly destroyed virus array,meanwhile, the infected cells that treated by the medicine kept healthy also.</p><p><b>CONCLUSION</b>ZDHY could not defend the infection of RSV, but is able to destroy the RSV directly and inhibit the RSV inhabiting in the cell.</p>