Therapeutic effect of photodynamic treatment for psoriasis vulgaris in guinea pigs / 南方医科大学学报
Journal of Southern Medical University
;
(12): 844-848, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-332536
ABSTRACT
<p><b>OBJECTIVE</b>To observe the efficacy of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating psoriasis vulgaris in guinea pigs.</p><p><b>METHODS</b>Experimental psoriasis vulgaris was induced in guinea pigs by application of 5% propranolol on the ear skin. After dressing of the skin lesion with 20% ALA solution for 4 h, the lesions were irradiated with a semiconductor laser at the wavelength of 635 nm and energy density of 12 J/cm(2). The guinea pigs were divided into control group, ALA only group, light only group, single ALA-PDT treatment group and twice ALA-PDT treatment group. In each group, gross observation and biopsy of the skin lesions was conducted on days 7, 14, 21 and 28 after the treatment.</p><p><b>RESULTS</b>In terms of gross observation of the lesion, epidermal thickness and proliferating cell nuclear antigen (PCNA) expression, ALA-PDT treatment showed obvious therapeutic effect on the skin lesion, and two treatment sessions resulted in better effect than a single session.</p><p><b>CONCLUSION</b>ALA-PDT can cure psoriasis vulgaris lesions characterized by abnormal epidermal proliferation in guinea pigs, and multiple treatment sessions can achieve better effects.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Photochemotherapy
/
Psoriasis
/
Photosensitizing Agents
/
Acne Vulgaris
/
Therapeutic Uses
/
Drug Therapy
/
Aminolevulinic Acid
/
Guinea Pigs
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article
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