Association of peripheral blood hypoxia-inducible factor-1α with metastasis of colorectal cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 705-706, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-332569
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between hypoxia-inducible factor-1α (HIF-1α) mRNA levels in the peripheral blood and the metastasis of colorectal cancer.</p><p><b>METHODS</b>HIF-1α mRNA in the peripheral blood was detected by RT-PCR in 40 patients with colorectal cancer and 20 healthy subjects.</p><p><b>RESULTS</b>Seventeen patients with colorectal cancer showed positivity for HIF-1α mRNA, showing a significantly higher positivity rate (42.5%) than the healthy subjects (P<0.05). The expression of HIF-1α mRNA is closely related to the staging of colorectal cancer (CRC).</p><p><b>CONCLUSION</b>HIF-1α mRNA may serve as a potential marker in the detection of metastasis of colorectal cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Blood
/
RNA, Messenger
/
Colorectal Neoplasms
/
Adenocarcinoma
/
Case-Control Studies
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Genetics
/
Neoplasm Invasiveness
/
Neoplasm Metastasis
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article
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