Effect of WT1 Gene High Expression and CD34and Aueron Prognosis of Acute Myeloid Leukemia / 中国实验血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the clinical significance of WT1 expression level in patient with AML non-M3,understand the biological characteristics of Auerand CD34AML and its effects on first induced remission rate and prognosis.</p><p><b>METHODS</b>The RQ-PCR was used to detect the WT1 expression levels in 92 patients suffering AML non-M3; the relationship between the CR1 and OS was analysed and the differences of CR1 and OS in AML with Auerand Auer,CD34and CD34were compared.</p><p><b>RESULTS</b>AML with WT1 high expression level at first visit had quite lower CR1 (P<0.05). AML with CD34had quite lower CR1 (P<0.05). Compared with Auerpatients, CR1 of AuerCML patients was higher (P<0.05), the OS of AML patients with WT1 high expression level was lower than that of the AML patients with low expression level of WT1, and with significant differences (P<0.05), the OS of AML patients with CD34was lower than that of AML patients with CD34, and with significant differences (P<0.05). There was no obvious difference in OS between the AML patients with Auerand Auer.</p><p><b>CONCLUSION</b>High expression level of WT1 and CD34in AML patients suggests the poor prognosis. The Auer positive only relats with CR1, and does not relate with OS.</p>