Effect of RBC Transfusion on T Lymphocyte Subsets of Patients with Hematologic Malignancies / 中国实验血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the effect of red blood cell(RBC) transfusion on T lymphocyte subsets in the patients with hematologic malignancies.</p><p><b>METHODS</b>The patients admitted in department of hematology of the second hospital of Shanxi Medical University from September 2013 to September 2014 acconuted for 144 cases had been diagnosed with hematologic malignancies and needed RBC transfusions according to clinical transfusion creteria (Hb level<70 g/L). All the patients were in rest period after chemotherapy, furthermore they did not administrate immunomodulatory drugs. The T lymphocyte subsets in these patients were detected by flow cytometry before and within 1 month after RBC transfusion, and the effect of RBC transfusion on T lymphocyte subsets was analysed.</p><p><b>RESULTS</b>Compared with those before red blood transfusion, the CD3cells, CD3CD4cells, CD3CD8cells of the patients with hematologic malignancies increased within 10 days after transfusion of red blood cells with statistical significance (P<0.05), while the CD3CD8cells of 59 patients with hematologic malignancies raised within 10 days to 30 days after red blood transfusion when compared with that before blood cell transfusion. However,CD3CD4,Th/Ts of these patients were decreased significantly(P<0.05) as compared with those before transfusion. Hematological malignancies of AML, ALL, MDS and MM showed different changes of T lymphocyte subsets before and after red blood cell transfusion.</p><p><b>CONCLUSION</b>T lymphocyte subsets are affected by red blood cell transfusion for the patients with hematologic malignancies. At the begining of red blood cells transfusion the cellular immune function is slightly enhanced or unchanged. As the immune response carring out, the inhibited cells are dominant and the cellular immune function is suppressed.</p>