Infection Status and Prognosis Analysis of Epstein-Barr Virus in Patients with Newly Diagnosed Hodgkin's Lymphoma / 中国实验血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the Epstein Barr virus(EBV) positive rate in newly diagnosed Hodgkin's lymphoma(HL) and the prognostic significance of EBV status.</p><p><b>METHODS</b>A total of 120 previously untreated patients with histologically confirmed Hodgkin's lymphoma were enrolled in this study. The EBV infection status was confirmed through examining EBV-RNA(EBER) or EBV latent membrane protein-1, and these patients were divided into EBV positive group and EBV negative group. The correlation of clinical features and EBV infection status was analyzed. For analysis of prognostic significance of EBV infection, the patients were divided into dead and survival groups, and the factors affecting the living conditions were analyzed.</p><p><b>RESULTS</b>Among 120 patients with HL, 36 patients(30.0%) were found with EBV infection. In EBVHL group patients were male, aged 6-15 and 61-74, the proportion of patients with mixed cellular sybtype was significantly higher than that in EBVHL group(P<0.05). The 1 year and 2 year total survival rate of patients in EBVgroup were 88.9% and 83.3%, and significantly lower than 97.6% and 95.2% in EBVgroup. Out of the 120 patients with HL, 10 patients died(8.3%). In death group, patients aged 61-74 and did not received radiotherapy, their proportion of EBVinfection was significantly hyher than that in survival group (P<0.05). Multiriabl analysis showed that the age 61-74 and EBVinfection were the risk factors for survival coditions of patients (P<0.05).</p><p><b>CONCLUSION</b>The EBV infection relates with HL, the clinical featuses of HL patients with EBVor EBVare different, the total survival time of patients in EBVgroup is shorter than that of patients in EBVgroup, the EBVinfection is a risk factor for total survival time of patients with HL.</p>