Advances in immunotherapy of hematological malignancies by using chimeric antigen receptor-modified lymphocytes / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 521-525, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-332744
ABSTRACT
Chimeric antigen receptors (CAR) are fusion proteins between single-chain variable fragments (scFv) from monoclonal antibodies and signaling domains of T-cells, which allow T-cells recognize specific cell-surface targets in an MHC-unrestricted fashion. The structure of CAR has changed over time, from first generation CAR (scFv + signaling moiety) to 2 and 3 generation CAR (combined with one or multiple costimulatory endodomains, such as CD28, 4-1BB and OX40), which enhance persistence, expansion and cytotoxicity of CAR. Many clinical trials treating hematological malignancies using the CAR-modified T-cells targeting CD19 and CD20 are under evaluation or even finished. These clinical trials indicated that CAR-based immunotherapy prolonged the survival of patients with relapsed/refractory B-cell malignancies. Furthermore, CAR have being studied to translate to other fields like adoptive therapy after hematopoietic stem cell transplantation. As to the treatment toxicity, CAR modified T-cell infusion is tolerant and safe in most patients. However, insertional mutagenesis, off-target effect and inflammatory response are safety issues surrounding CAR-modified T-cell therapy. In this review, the use of CAR technique in treatment of hematologic malignancies and evaluation of CAR safety are summarized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Recombinant Fusion Proteins
/
Receptors, Antigen
/
T-Lymphocytes
/
Hematologic Neoplasms
/
Allergy and Immunology
/
Cell- and Tissue-Based Therapy
/
Immunotherapy
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2013
Type:
Article
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