Repair of radius defect with bone-morphogenetic-protein loaded hydroxyapatite/collagen-poly(L-lactic acid) composite / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 67-74, 2003.
Article
in English
| WPRIM
| ID: wpr-332915
ABSTRACT
<p><b>OBJECTIVE</b>To explore the method to repair bone defect with bone-morphogenetic-protein loaded hydroxyapatite/collagen-poly(L-lactic acid) composite.</p><p><b>METHODS</b>18 adult beagle dogs were randomly divided into 3 groups. In Group A, bone-morphogenetic-protein (BMP) loaded hydroxyapatite/collagen-poly(L-lactic acid) (HAC-PLA) scaffold was implanted in a 2 cm diaphyseal defect in the radius. In Group B, unloaded pure HAC-PLA scaffold was implanted in the defects. No material was implanted in Group C (control group). The dogs were sacrificed 6 months postoperatively. Features of biocompatibility, biodegradability and osteoinduction were evaluated with histological, radiological examinations and bone mineral density (BMD) measurements.</p><p><b>RESULTS</b>In Group A, the radius defect healed after the treatment with BMP loaded HAC-PLA. BMD at the site of the defect was higher than that of the contralateral radius. Fibrous union developed in the animals of the control group.</p><p><b>CONCLUSIONS</b>BMP not only promotes osteogenesis but also accelerates degradation of the biomaterials. Optimized design parameters of a three-dimensional porous biomaterial would give full scope to the role of BMP as an osteoinductive growth factor.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteogenesis
/
Pathology
/
Physiology
/
Radius
/
Wound Healing
/
Biocompatible Materials
/
Diagnostic Imaging
/
Microscopy, Electron, Scanning
/
Radiography
/
Osseointegration
Type of study:
Diagnostic study
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Traumatology
Year:
2003
Type:
Article
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