Effects of SUMOylation on the subcellular localization and function of DAXX / 生理学报
Acta Physiologica Sinica
;
(6): 89-95, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-333130
ABSTRACT
Death domain-associated protein (DAXX) as a multifunctional nuclear protein widely resides in nucleolus, nucleoplasm, chromatin, promyelocytic leukaemia nuclear bodies (PML-NBs) and cytoplasm. It plays significant roles in transcriptional regulation, apoptosis, cell cycle and other biological activities. Small ubiquitin-like modifier (SUMO) is required for SUMOylation which is a highly conserved post-translational modification in a wide variety of cellular processes. Numerous studies demonstrated that SUMOylation has a great effect on the subcellular localization and functional regulation of DAXX. This review will provide a summary for SUMOylation of DAXX.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Nuclear Proteins
/
Gene Expression Regulation
/
Adaptor Proteins, Signal Transducing
/
Sumoylation
Limits:
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2013
Type:
Article
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