P21-activated kinases and their role in the nervous system / 生理学报
Acta Physiologica Sinica
;
(6): 700-706, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-333151
ABSTRACT
P21-activated kinases (PAK) participate in a variety of important cellular activities, such as cytoskeleton remodeling, cell migration, cell cycle regulation, and apoptosis or survival. PAK also has an important impact on brain development, neuronal differentiation, and regulation of synaptic plasticity in the nervous system. PAK abnormalities result in diseases including cancer, Parkinson's disease (PD), Alzheimer's disease (AD) and neural retardation. Therefore, it is of vital physiological significance to investigate the neuronal function of PAK. In this paper we review the advancement of research on the neuronal biological function and the underlying mechanisms of PAK.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Physiology
/
Cytoskeleton
/
Cell Cycle
/
Cell Movement
/
Apoptosis
/
P21-Activated Kinases
/
Alzheimer Disease
/
Nervous System
/
Neuronal Plasticity
Limits:
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2012
Type:
Article
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