Expression of BRG1 and BRM proteins in prostatic cancer / 中华病理学杂志
Chinese Journal of Pathology
;
(12): 591-594, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-333203
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of BRG1 and BRM, the catalytic subunits expressed by SWI/SNF, in benign and malignant prostatic tissues and to correlate the BRG1/BRM expression with the development and progression of prostatic cancer.</p><p><b>METHODS</b>The expression levels of the BRG1 and BRM proteins in benign and malignant prostatic tissues were studied using semi-quantitative immunohisto-chemistry. The results correlated with various clinical and pathologic parameters.</p><p><b>RESULTS</b>The average immuno-reactive score for BRG1 expression in prostatic cancer tissues was significantly higher than that in benign prostatic tissues (57+/-9.8 and 19+/-4.1, respectively, P = 0.000 17). The difference was more obvious in the high-grade cancer. On the other hand, BRM expression exhibited a heterogeneous pattern. The average immuno-reactive score for BRM expression was lower in cancer tissues than in benign tissues (112+/-17 and 151+/-19, respectively, P = 0.0047). BRG1 and BRM demonstrated a reciprocal expression pattern in benign and malignant tissues. The average immuno-reactive score for BRG1 expression was higher in the cancer cases with a larger tumor volume than in the cases with a smaller tumor volume (P = 0.0112).</p><p><b>CONCLUSIONS</b>The expression of BRG1 and BRM correlates with the development of prostatic cancer. Increased BRG1 expression may have certain implications in tumor progression.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prostate
/
Prostatic Neoplasms
/
Transcription Factors
/
Nuclear Proteins
/
Gene Expression Regulation, Neoplastic
/
DNA Helicases
/
Disease Progression
/
Tumor Burden
/
Metabolism
Limits:
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pathology
Year:
2010
Type:
Article
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