DNA methylation of human telomerase reverse transcriptase promoter region in human ameloblastoma / 中华口腔医学杂志
Chinese Journal of Stomatology
; (12): 304-307, 2007.
Article
in Zh
| WPRIM
| ID: wpr-333336
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the DNA methylation of human telomerase reverse transcriptase (hTERT) promoter in ameloblastoma (AB) and investigate its clinical biological significance.</p><p><b>METHODS</b>DNA methylation of hTERT promoter in 12 cases of AB and 11 cases of normal oral mucosa were detected by methylation-specific PCR.</p><p><b>RESULTS</b>The positive cases of unmethylated hTERT promoter region in AB and normal oral mucosa were 4 (4/12) and 6 (6/11), respectively (P < 0.001). The positive cases of methylated hTERT promoter region in AB and normal oral mucosa were 11 (11/12) and 3 (3/11), respectively. Four cases of AB and 1 case of normal oral mucosa showed both DNA methylation and unmethylation of hTERT promoter region in the same time.</p><p><b>CONCLUSIONS</b>DNA methylation of of hTERT promoter region in AB was more common than that in normal oral mucosa. The DNA methylation in hTERT promoter maybe regulate hTERT gene expression.</p>
Full text:
1
Index:
WPRIM
Main subject:
Ameloblastoma
/
Jaw Neoplasms
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Gene Expression Regulation, Neoplastic
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Promoter Regions, Genetic
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Telomerase
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DNA Methylation
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Genetics
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Stomatology
Year:
2007
Type:
Article