Comparative Maternal and Neonatal Effects of Propofol, Propofol-Ketamine and Ketamine as Induction Agents in Cesarean Section / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 653-659, 1997.
Article
in Korean
| WPRIM
| ID: wpr-33357
ABSTRACT
BACKGROUND:
Propofol and ketamine had been used for anesthesia induction and for total intravenous anesthesia. The nature of any hypnotic interactions occurring between propofol and ketamine are unknown. A comparison of maternal and neonatal effects among propofol-ketamine combination, ketamine and propofol were studied when used for anesthesia induction in Cesarean section.METHODS:
Forty five patients in ASA class I or II scheduled for Cesarean section randomly assigned to either propofol 2 mg/kg (n=15), ketamine 1 mg/kg (n=15) or propofol 1 mg/kg - ketamine 0.5 mg/kg combination group (n=15) as an induction agent. Maternal systolic and diastolic blood pressure, heart rate, Apgar score and umbilical blood gas analysis were measured.RESULTS:
Before intubation, systolic and diastolic pressure were decreased in propofol group but increased in ketamine and propofol-ketamine combination group. Heart rate were increased in all three groups. But there were no significant differences among three groups (p<0.05). After intubation, there were significant increase in systolic, diastolic pressure and heart rate in three groups but no significant differences among three groups (p<0.05). And there was no significant neonatal depression as assessed by Apgar scores and blood gas analyses.CONCLUSIONS:
Propofol-ketamine combination was found to be similar to propofol or ketamine only in the effects on the mother and neonate. But propofol-ketamine gained more stable hemodynamic change than propofol or ketamine before intubation. Therefore propofol-ketamine appears to be a suitable alternatives to propofol or ketamine as an induction agent for anesthesia in Cesarean section.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apgar Score
/
Blood Gas Analysis
/
Blood Pressure
/
Propofol
/
Cesarean Section
/
Depression
/
Heart Rate
/
Hemodynamics
/
Intubation
/
Anesthesia
Limits:
Female
/
Humans
/
Infant, Newborn
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1997
Type:
Article
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