Expression of transient receptor potential lvanilloidreceptor 4 protein in autoimmune bullous skin disorders / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1349-1351, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-333626
ABSTRACT
<p><b>OBJEVTIVE</b>To investigate the expression of transient receptor potential lvanilloidreceptor 4 (TRPV4) protein in pemphigus vulgaris (PV), bullous pemphigoid (BP), dermatitis herpetiformis (DH), and epidermolysis bullosa acquisita (EBA), and explore the role of TRPV4 in the pathogenesis of these diseases.</p><p><b>METHODS</b>TRPV4 protein in normal skin tissues and lesions of PV, BP, DH, and EBA were detected with immunohistochemistry.</p><p><b>RESULTS</b>The positivity rate of TRPV4 protein expression was 61.90% in PV, 81.81% in BP, 72.22% in DH, and 68.42% in EBA. TRPV4-positive rates in these lesions were significantly lower than the rate in normal skin tissues (93.33%) and also differed significantly among these lesions (PV<EBA<DH<BP).</p><p><b>CONCLUSIN</b>Low TRPV4 expressions may affect the formation and reconstitution of skin connection. TRPV4 may play an role in the occurrence and development of autoimmune bullous skin disorders.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Skin
/
Epidermolysis Bullosa Acquisita
/
Dermatitis Herpetiformis
/
Pemphigoid, Bullous
/
Pemphigus
/
Diagnosis, Differential
/
TRPV Cation Channels
/
Metabolism
Type of study:
Diagnostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2015
Type:
Article
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