Does Heparin Reduce Neurologic Injury in Rabbits That Occurs From Air Emboli? / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 604-609, 1997.
Article
in Korean
| WPRIM
| ID: wpr-33364
ABSTRACT
BACKGROUND:
Neurological injury after cerebral air embolism may be due to thromboinflammatory responses at sites of air-injured endothelium. Because heparin inhibits multiple thromboinflammatory processes. we hypothesized that heparin would decrease neurological impairment after cerebral air embolism.METHODS:
Anesthetized rabbits received either heparin (n=14) or saline (n=13), 5 minutes before air injection (150 microliter/kg). Heparin was given as a 200 IU/kg bolus and followed by a constant infusion of 75 IU/kg/h for 2 hours. Equal volumes of salines were given to saline group. Two hours later, anesthesia was discontinued. Rabbits were neurologically evaluated 24 hours after air embolism.RESULTS:
Heparin group had significantly less neurological impairment at 24 hours (34 14) than saline controls (52 8) (p=0.0013).CONCLUSIONS:
When given prophylactically, heparin decreases neurological impairment caused by severe cerebral arterial air embolism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Heparin
/
Embolism, Air
/
Endothelium
/
Anesthesia
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
1997
Type:
Article
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