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Nodal tumor response according to the count of peripheral blood lymphocyte subpopulations during preoperative chemoradiotherapy in locally advanced rectal cancer
Radiation Oncology Journal ; : 305-312, 2016.
Article in English | WPRIM | ID: wpr-33370
ABSTRACT

PURPOSE:

The objective of this prospective study was to evaluate the relationship between the circulating lymphocyte subpopulation counts during preoperative chemoradiotherapy (CRT) and tumor response in locally advanced rectal cancer. MATERIALS AND

METHODS:

From August 2015 to June 2016, 10 patients treated with preoperative CRT followed by surgery were enrolled. Patients received conventional fractionated radiotherapy (50.4 Gy) with fluorouracil-based chemotherapy. Surgical resection was performed at 4 to 8 weeks after the completion of preoperative CRT. The absolute blood lymphocyte subpopulation was obtained prior to and after 4 weeks of CRT. We analyzed the association between a tumor response and change in the lymphocyte subpopulation during CRT.

RESULTS:

Among 10 patients, 2 (20%) had evidence of pathologic complete response. In 8 patients with clinically node positive, 4 (50%) had nodal tumor response. All lymphocyte subpopulation counts at 4 weeks after CRT were significantly lower than those observed during pretreatment (p < 0.01). A high decrease in natural killer (NK) cell, count during CRT (baseline cell countcell count at 4 weeks) was associated with node down staging (p = 0.034).

CONCLUSION:

Our results suggest that the change of lymphocyte subset to preoperative CRT may be a predictive factor for tumor response in rectal cancer.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Radiotherapy / Rectal Neoplasms / Killer Cells, Natural / Lymphocytes / Cell Count / Prospective Studies / Lymphocyte Subsets / Drug Therapy / Chemoradiotherapy Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Radiation Oncology Journal Year: 2016 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Radiotherapy / Rectal Neoplasms / Killer Cells, Natural / Lymphocytes / Cell Count / Prospective Studies / Lymphocyte Subsets / Drug Therapy / Chemoradiotherapy Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Radiation Oncology Journal Year: 2016 Type: Article