Effect of high-frequency stimulation to subthalamic nucleus on STR neuronal firing rates in Parkinson disease rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 83-87, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-333709
ABSTRACT
<p><b>AIM</b>To observe the change of STR neuronal firing rates with high frequency stimulation of subthalamic nucleus in PD rats.</p><p><b>METHODS</b>A model of Parkinson's disease was induced by unilateral administration of 6-hydroxydopamine into right substantia nigra in rats. After the high-frequency stimulation to STN, the spontaneous firing rates of STR on normal and PD rats were recorded by using extracellular recordings.</p><p><b>RESULTS</b>Stimulation caused a direct excited effect of STR neurons in normal rats whereas a excited and inhibited effect in PD rats. The inhibited effect was correlated with the stimulation period (r = 0.94).</p><p><b>CONCLUSION</b>Stimulation to STN may inhibit the spontaneous firing rates of STR neurons in PD rats. These results also give some clues that high-frequency stimulation to STN may be a effective therapy to the clinical treatment of Parkinson's disease.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parkinson Disease
/
Physiology
/
Therapeutics
/
Action Potentials
/
Electric Stimulation Therapy
/
Rats, Sprague-Dawley
/
Corpus Striatum
/
Subthalamic Nucleus
/
Disease Models, Animal
/
Neurons
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2004
Type:
Article
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