Effect of corticosterone on the delayed rectified potassium currents of cultured rat hippocampal neurons in vitro / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>The effect of stress hormone corticosterone on hippocampal neurons delayed rectified potassium currents was probed.</p><p><b>METHODS</b>The potassium currents of rat hippocampal neurons in primary culture were measured with patch clamp whole-cell recording.</p><p><b>RESULTS</b>It showed that the amplitudes of the potassium currents in hippocampal neurons decreased. However, the threshold potential of potassium currents increased.</p><p><b>CONCLUSION</b>It is speculated that excessive corticosterone may hurt the hippocampal neurons via its effects on the potassium currents of rat hippocampal cells.</p>