Effect of CoCl2 pretreatment on Na + and K+ currents of the rat hippocampal neurons after acute hypoxia / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 250-252, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-333786
ABSTRACT
<p><b>AIM</b>To study effect of CoCl2 pretreatment on the voltage-gated Na+ and K+ currents of the rat hippocampal neurons after acute hypoxia.</p><p><b>METHODS</b>Primarily cultured hippocampal neurons were divided into CoCl2 pretreated and non-pretreated groups. Patch clamp whole cell recording technique was used to examine Na+ and K+ currents of the hippocampal neurons.</p><p><b>RESULTS</b>After acute hypoxia, I(Na) and I(K) of the hippocampal neurons were significantly decreased and the threshold of I(Na) was right-shifted. Pretreatment of the neurons with CoCl2 inhibited the reduction of I(Na) and I(K).</p><p><b>CONCLUSION</b>CcCl2 pretreatment alleviates the acute hypoxia-induced changes of I(Na) and I(K), which may be one of the mechanisms for the protective effect of CoCl2 on neurons.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Potassium Channels
/
Sodium Channels
/
Cell Hypoxia
/
Rats, Wistar
/
Cobalt
/
Patch-Clamp Techniques
/
Cell Biology
/
Hippocampus
/
Animals, Newborn
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2003
Type:
Article
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