Study on the oral bio-availability of artemisinin solid dispersion system using Eudragit 100 as a carrier
Pharmaceutical Journal
;
: 17-20, 1999.
Article
in Vietnamese
| WPRIM
| ID: wpr-3338
ABSTRACT
The oral Bio-availability of two different capsule formulations of artmisinin was carried out in six rabbits divided in two groups and seven healthy male volunteers in a single-dose crossover design with randomization for dosing sequence. The experimental results showed that the relative bioavailability of the formulation, that was made of artemisinin solid dispersion system using Eudragit L100 as a carrier on ratio 11, was more two times higher than the modification of artemisinin capsules without any modifications. There was a good correlation between in vitro dissolution data obtained by dissolution test with the mean AUG values of each studied group after oral administration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Pharmaceutical Preparations
Type of study:
Controlled clinical trial
Language:
Vietnamese
Journal:
Pharmaceutical Journal
Year:
1999
Type:
Article
Similar
MEDLINE
...
LILACS
LIS