Bioequivalence of pyridostigmine bromide dispersible tablets in rabbits / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1778-1780, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-333814
ABSTRACT
<p><b>OBJECTIVE</b>To compare the pharmacokinetic parameters of pyridostigmine bromide dispersible tablets and common tablets in rabbits.</p><p><b>METHODS</b>Twelve rabbits were given an oral dose (60 mg) of pyridostigmine bromide dispersible tablets or common tablets in a randomized crossover study. The plasma concentration of pyridostigmine bromide was determined by reversed-phase ion pair chromatography. The pharmacokinetic parameters were calculated using DAS2.1.1 software.</p><p><b>RESULTS</b>The pharmacokinetic parameters showed no significant differences in rabbit plasma between pyridostigmine bromide dispersible tablets and common tablets. The two tablets had a C(max) of 1.83∓0.08 mg·L(-1) and 1.68∓0.03 mg·L(-1), tmax of 2.33∓0.41 h and 2.58∓0.20 h, AUC(0-24) of 15.50∓0.62 mg·h·L(-1) and 15.14∓0.30 mg·h·L(-1), AUC(0-∞) of 15.82∓0.70 mg·h·L(-1) and 15.57∓0.32 mg·h·L(-1), respectively. The relative bioavailability F(0-24) was 102.38% and F(0-∞) was 101.61% for the dispersible tablets.</p><p><b>CONCLUSION</b>The two tablets are bioequivalent in rabbits.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pyridostigmine Bromide
/
Tablets
/
Blood
/
Pharmacokinetics
/
Biological Availability
/
Therapeutic Equivalency
/
Administration, Oral
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article
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