Safety and efficacy of Sorafenib in treatment of tumor recurrence in liver transplantation recipients / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1608-1610, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-333851
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the therapeutic effect and safety of Sorafenib in the treatment of tumor recurrence after orthotopic liver transplantation (OLT).</p><p><b>METHODS</b>Between January, 2009 and June, 2011, 10 patients with tumor recurrence after OLT were treated with Sorafenib (group A) and another 8 recipients received no Sorafenib treatment (group B); 25 patients with hepatocellular carcinoma (HCC) also received Sorafenib treatment (group C). The tumor-bearing survival time, adverse effect and toxicity associated with sorafenib were compared between the 3 groups.</p><p><b>RESULTS</b>In group A, the median tumor-bearing survival time was 10 months (5-22 months), as compared to 4 months (1-8 months) in group B and 4 months (2-21 months) in group C, showing a significant difference in the survival time among the 3 groups (Kaplan-Meier, log-rank test, P=0.045). No recipient experienced acute graft rejection, but one recipient in group A died due to gastrointestinal bleeding. No significant difference was found in adverse effects associated with Sorafenib between groups A and C (P<0.05).</p><p><b>CONCLUSION</b>Sorafenib can prolong the survival time of patients with tumor recurrence after OLT without increasing the risk of acute graft rejection.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenylurea Compounds
/
Postoperative Period
/
General Surgery
/
Survival Rate
/
Liver Transplantation
/
Treatment Outcome
/
Niacinamide
/
Carcinoma, Hepatocellular
/
Therapeutic Uses
/
Drug Therapy
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article
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