Expression of translationally controlled tumor protein in human breast cancer and its clinical significance / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1560-1563, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-333864
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of translationally controlled tumor protein (TCTP) in human breast cancer tissues and its clinical significances.</p><p><b>METHODS</b>The expression of TCTP in 94 human breast cancer and the corresponding adjacent normal mammary tissues were detected using immunohistochemistry.</p><p><b>RESULTS</b>The expression rate of TCTP was 64.89% in human breast cancer tissues, significantly higher than that in normal benign mammary tissues (39.36%, P<0.001). TCTP overexpression was positively correlated to the tumor size, clinical stage, lymph node metastasis and histological grade of breast cancer (P<0.05). Patients with positive TCTP expression had a significantly shorter mean survival time than those with negative expression (P<0.001).</p><p><b>CONCLUSION</b>TCTP may play an important role in the tumorigenesis and development of breast cancer, and can be an important prognostic factor for this malignancy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Breast Neoplasms
/
Biomarkers, Tumor
/
Metabolism
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article
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