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Development of a time-resolved fluoroimmunoassay for detecting S1 subunit of pertussis toxin and its application / 南方医科大学学报
Journal of Southern Medical University ; (12): 1509-1512, 2011.
Article in Chinese | WPRIM | ID: wpr-333876
ABSTRACT
<p><b>OBJECTIVE</b>To develop a time-resolved fluoroimmunoassay (TRFIA) for detection of pertussis toxin (PT) S1 subunit for quality control of human PT vaccine.</p><p><b>METHODS</b>A double antibody sandwich one-step method was used to establish the TRFIA for detecting PT S1 subunit in the vaccine.</p><p><b>RESULTS</b>The sensitivity of c peptide analysis reached 2.5 ng/ml without cross-reactions with other antigens. This assay could be used in detecting S1 subunit in the vaccine.</p><p><b>CONCLUSION</b>The TRFIA for detecting PT S1 subunit is simple, sensitive and rapid for quality control of the PT vaccine.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality Control / Reference Standards / Pertussis Vaccine / Fluoroimmunoassay / Chemistry / Sensitivity and Specificity / Cross Reactions / Pertussis Toxin / Methods Type of study: Diagnostic study Language: Chinese Journal: Journal of Southern Medical University Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Quality Control / Reference Standards / Pertussis Vaccine / Fluoroimmunoassay / Chemistry / Sensitivity and Specificity / Cross Reactions / Pertussis Toxin / Methods Type of study: Diagnostic study Language: Chinese Journal: Journal of Southern Medical University Year: 2011 Type: Article