Efficacy of trsatuzumab (Herceptin) combined with FOLFIRI regimen in the treatment of HER2-positive advanced gastric cancer / 南方医科大学学报
Journal of Southern Medical University
; (12): 1458-1460, 2011.
Article
in Zh
| WPRIM
| ID: wpr-333887
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the safety and efficacy of trsatuzumab (Herceptin) combined with FOLFIRI regimen (irinotecan plus 5-FU/LV) in the treatment of HER2-positive advanced gastric cancer.</p><p><b>METHODS</b>T Thirty-four patients with pathologically confirmed advanced gastric cancer, all positive for the human epidermal growth factor receptor 2 (HER2) as identified by immunohistochemistry and fluorescence in situ hybridization, were randomized into the test group and control group to for treatment with the combined regimen and the FOLFIRI regimen alone, respectively. FOLFIRI regimen was administered every 2 weeks for 2 to 4 cycles. Trsatuzumab was given intravenously on a weekly basis with an initial dose of 4 mg/kg and a subsequent dose of 2 mg/kg. All the patients were assessed for efficacy and toxicity of the treatments.</p><p><b>RESULTS</b>The overall response rate was 58.8% in the test group and 35.3% in the control group, with disease control rates of 88.2% and 64.7%, respectively, showing significant differences between the two groups (P<0.05). The most frequent grade I/II treatment-related adverse events included diarrhea, nausea/vomiting and neutropenia.</p><p><b>CONCLUSION</b>Trsatuzumab combined with FOLFIRI regimen is effective, safe and well tolerated for treatment of HER2-positive advanced gastric cancer.</p>
Full text:
1
Index:
WPRIM
Main subject:
Stomach Neoplasms
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Camptothecin
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Adenocarcinoma
/
Antineoplastic Combined Chemotherapy Protocols
/
Leucovorin
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Receptor, ErbB-2
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Therapeutic Uses
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Drug Therapy
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Antibodies, Monoclonal, Humanized
/
Trastuzumab
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Adult
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Aged
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Female
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Humans
/
Male
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article