Expression of deleted in liver cancer 1 and phosphorelated focal adhesion kinase in breast cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1448-1451, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-333889
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the expression of deleted in liver cancer 1 (DLC1) and phosphorelated focal adhesion kinase (p-FAK) in breast cancer tissue to further understand the molecular mechanisms of the carcinogenesis and metastasis of breast cancer.</p><p><b>METHODS</b>Immunohistochemistry was employed to determine the protein level of DLC1 and p-FAK in 61 breast cancer, 30 benign breast disease and the adjacent normal breast tissues.</p><p><b>RESULTS</b>The positivity rates of DLC1 differed significantly between breast cancer, benign and normal tissues (34.43%, 80.00% and 76.67%, respectively, P<0.001). The positivity rates of p-FAK in the 3 tissues were 77.05%, 33.33% and 26.67%, also showing significant differences (P<0.001). The aberrant expression of DLC1 showed an inverse correlation to p-FAK (κ=-0.4591). Both DLC1 and p-FAK were closely correlated to the carcinogenesis, clinical stage, PR and lymphatic metastasis of breast cancer (P<0.05), but not to the patients age, pathological subtype, familial history, ER or CerbB-2 (P>0.05).</p><p><b>CONCLUSION</b>The abnormal expression of DLC1 and p-FAK might participate in the carcinogenesis, progression, and metastasis of breast cancer. The role of DLC1 and p-FAK might be related to the regulation of progestone. DLC1 and p-FAK may serve as candidate markers for early diagnosis, prognostic evaluation and target treatment of breast cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Phosphorylation
/
Prognosis
/
Breast Neoplasms
/
Receptors, Progesterone
/
Carcinoma, Ductal, Breast
/
GTPase-Activating Proteins
/
Tumor Suppressor Proteins
/
Focal Adhesion Kinase 1
/
Lymphatic Metastasis
Type of study:
Prognostic study
/
Screening study
Limits:
Adult
/
Female
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2011
Type:
Article
Similar
MEDLINE
...
LILACS
LIS