A Case of Pulmonary Embolism in a Patient with a Factor VII Gene Promoter -401G/A Polymorphism / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 466-470, 2008.
Article
in Korean
| WPRIM
| ID: wpr-33398
ABSTRACT
A factor VII gene -401 G/A polymorphism was identified in a patient with a pulmonary embolism. The patient was a 71-year-old woman who presented with acute-onset dyspnea. A chest CT scan revealed a pulmonary embolism. Despite the administration of low-dose warfarin as anticoagulation therapy, there was an excessively prolonged prothrombin time (PT). The blood tests revealed lower factor VII activity than normal. Full factor VII gene sequencing revealed a G to A substitution at ?401 in the promoter region. There were no other gene sequence anomalies. PCR-based analysis indicated lower factor VII gene expression in the patient than in a control subject. The data suggested the promoter polymorphism to be responsible for the lower transcription level. In conclusion, we encountered a case of Factor VII DNA polymorphism in a patient with a pulmonary embolism showing significantly reduced Factor VII activity.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Prothrombin Time
/
Pulmonary Embolism
/
Thorax
/
Warfarin
/
DNA
/
Factor VII
/
Gene Expression
/
Promoter Regions, Genetic
/
Dyspnea
Type of study:
Prognostic study
Limits:
Aged
/
Female
/
Humans
Language:
Korean
Journal:
Tuberculosis and Respiratory Diseases
Year:
2008
Type:
Article
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