Tyrosine kinase mutation and acute myeloid leukemia with T (8; 21) / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 866-869, 2009.
Article
in Zh
| WPRIM
| ID: wpr-334007
Responsible library:
WPRO
ABSTRACT
This study was aimed to investigate the status of c-KIT, Fms-like tyrosine kinase 3 (FLT3) and Janus kinase 2 (JAK2) mutations in acute myeloid leukemia (AML) patients with t (8; 21) and to analyze their relation to clinical feature and prognosis. PCR, AS-PCR, restriction and sequencing methods were used respectively to detect the FLT3, JAK 2 and c-KIT mutations in 8 cases of de novo AML with t (8; 21) and 6 cases of relapsed AML with t (8; 21). The results showed that the c-KIT mutation was found in 2 cases out of 14 AML patients with t (8; 21) (14.3%), among them 1 case had c-KIT D816V mutation, the other had c-KIT D816Y mutation. The FLT3-ITD mutation was detect in 1 out of 14 patients (7.1%), but JAK2 mutation could not be detected in all 14 cases. In conclusion, tyrosine kinase mutation relates to AML with t (8; 21), patients with tyrosine kinase mutation may have higher relapse, extramedullary infiltration and poor prognosis. The screening c-KIT, FLT3 mutations may play an important role in evaluating prognosis and guiding treatment of t (8; 21) AML.
Full text:
1
Index:
WPRIM
Main subject:
Leukemia, Myeloid, Acute
/
Proto-Oncogene Proteins c-kit
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Tandem Repeat Sequences
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Fms-Like Tyrosine Kinase 3
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Janus Kinase 2
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Genetics
/
Mutation
Type of study:
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Child
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Child, preschool
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Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2009
Type:
Article