Identification of a novel HLA allele DRB1*1462 by sequence-based typing / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 493-495, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-334084
ABSTRACT
This study was to identify a novel HLA-DRB1 allele in Chinese population by nucleotide sequence ana- lysis. The HLA typing of genes was performed by PCR-SSO and PCR-SSP, the ambiguous novel allele was identified by DNA sequence analysis. The results showed that the sequence of this new allele differed from DRB1*140101 by one nucleotide substitution at position 256 in exon 2 (G- > A), resulting in an amino acid change from Ala to Thr at codon 57. In conclusion, this allele is a novel one, which has been officially given the name DRB1*1462 by the WHO nomenclature committee in January 2006.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Histocompatibility Testing
/
Molecular Sequence Data
/
HLA-DR Antigens
/
Sequence Analysis, DNA
/
Asian People
/
Alleles
/
HLA-DRB1 Chains
/
Genetics
Type of study:
Diagnostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2009
Type:
Article
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