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Increased subthalamic neuronal activity after dorsal raphe nucleus lesion by 5,7-dihydroxytryptamine in the rat / 生理学报
Acta Physiologica Sinica ; (6): 83-90, 2005.
Article in Chinese | WPRIM | ID: wpr-334201
ABSTRACT
In vivo extracellular recordings were made in the subthalamic nucleus (STN) of intact control rats and rats with 5,7-dihydroxytryptamine (5,7-DHT) -produced lesion of dorsal raphe nucleus (DRN). The results showed that the firing rate of STN neurons in control rats and DRN-lesioned rats were (6.93+/-6.55) Hz and (11.27+/-9.31) Hz, respectively, and the firing rate of DRN-lesioned rats significantly increased when compared to the control rats (P<0.01). In control rats, 13% of STN neurons discharged regularly, 46% irregularly and 41% in bursts. In DRN-lesioned rats, 9% of STN neurons discharged regularly, 14% irregularly and 77% in bursts, the percentage of STN neurons firing in bursts was obviously higher than that of the control rats (P<0.01). In addition, the mean interspike interval coefficient of variation of STN neurons in control rats and DRN-lesioned rats were (0.05+/-0.04) and (0.11+/-0.09), respectively. The mean interspike interval coefficient of variation of DRN-lesioned rats was significantly higher than that of the control rats (P<0.001). These results show that the firing rate and the bursting pattern rate of neurons in STN of DRN-lesioned rats increase significantly, suggesting that DRN inhibits the neuronal activity of the subthalamic neurons in the intact rat.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Physiology / Raphe Nuclei / Random Allocation / Rats, Sprague-Dawley / Adrenergic Agents / Subthalamic Nucleus / 5,7-Dihydroxytryptamine / Electrophysiological Phenomena Limits: Animals Language: Chinese Journal: Acta Physiologica Sinica Year: 2005 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pharmacology / Physiology / Raphe Nuclei / Random Allocation / Rats, Sprague-Dawley / Adrenergic Agents / Subthalamic Nucleus / 5,7-Dihydroxytryptamine / Electrophysiological Phenomena Limits: Animals Language: Chinese Journal: Acta Physiologica Sinica Year: 2005 Type: Article