Vascular Endothelial Growth Factor-C Expression in Primary and Metastatic Brain Tumor
Journal of Korean Neurosurgical Society
;
: 543-547, 2002.
Article
in Korean
| WPRIM
| ID: wpr-33424
ABSTRACT
OBJECTIVE:
Vascular endothelial growth factor(VEGF)-C is involved in lymphangiogenesis and spreading of cancer cells via lymphatic vessels. The aim of the present study is to investigate the relationship between the absence of cerebral lymphatic vessels and low metastatic rate of brain tumors.METHODS:
Immunohistochemical stains were performed for VEGF-C and VEGF in surgically resected specimens from 57 patients with primary(38 cases, low grade 10 cases, high grade 28 cases) and metastatic(19 cases) brain tumor.RESULTS:
The expression of VEGF-C was higher in metastatic carcinoma(68%) than in high-grade primary tumor(29%). There was no difference for VEGF expression between high grade brain tumor (71%) and metastatic carcinoma(58%).CONCLUSION:
Low VEGF-C expression of primary brain tumors may play a role in low metastatic rate of brain tumors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Brain
/
Brain Neoplasms
/
Lymphatic Vessels
/
Vascular Endothelial Growth Factor A
/
Vascular Endothelial Growth Factor C
/
Lymphangiogenesis
/
Coloring Agents
Limits:
Humans
Language:
Korean
Journal:
Journal of Korean Neurosurgical Society
Year:
2002
Type:
Article
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