Your browser doesn't support javascript.
loading
Expression of integrin alpha 6 in hepatic sinusoidal capillaration / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 90-92, 2002.
Article in Chinese | WPRIM | ID: wpr-334306
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression of integrin alpha 6 in hepatic sinusoidal capillaration.</p><p><b>METHODS</b>The rat hepatic fibrosis model was established by injection of carbon tetrachloride subcutaneously. Then the expression of laminin and integrin alpha 6 subunit was observed by immunohistochemistry and dot immuno-blotting.</p><p><b>RESULTS</b>We observed sinusoidal capillaration formed by deposition of laminin along sinusoids in Disse interspace by immunohistochemistry staining. In normal rat the expression of integrin alpha 6 was restricted to portal vascular endothelial cells and bile duct epithelial cell membranes. No expression was observed in sinusoidal endothelial cell membranes. When capillaration integrin alpha 6 was detected in a continuous pattern along the sinusoids, the content of integrin alpha 6 was significantly higher in fibrotic liver tissues than in normal liver tissues as measured by dot immuno-blotting (P<0.05).</p><p><b>CONCLUSIONS</b>During fibrogenesis, laminin continuously accumulate in liver tissues and form basement membrane resulting in sinusoidal capillaration, and then induce the expression of integrin alpha 6 on SEC membranes.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Time Factors / Carbon Tetrachloride / Immunohistochemistry / Immunoblotting / Antigens, CD / Laminin / Rats, Wistar / Integrin alpha6 / Liver Type of study: Prognostic study Limits: Animals Language: Chinese Journal: Chinese Journal of Hepatology Year: 2002 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Time Factors / Carbon Tetrachloride / Immunohistochemistry / Immunoblotting / Antigens, CD / Laminin / Rats, Wistar / Integrin alpha6 / Liver Type of study: Prognostic study Limits: Animals Language: Chinese Journal: Chinese Journal of Hepatology Year: 2002 Type: Article