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Role of ¹²³I-BMIPP and serum B-type natriuretic peptide for the evaluation of patients with heart failure
Singapore medical journal ; : 398-402, 2012.
Article in English | WPRIM | ID: wpr-334468
ABSTRACT
<p><b>INTRODUCTION</b>Myocardial scintigraphy with ¹²³I-15-(p-iodophenyl)-3-methyl pentadecanoic acid (¹²³I-BMIPP) is used to evaluate impaired fatty acid metabolism. B-type natriuretic peptide (BNP), which is secreted by the ventricular myocardium on stretching and/or pressure overload, is a useful cardiac biomarker. This study aimed to evaluate the usefulness of ¹²³I-BMIPP imaging and serum BNP levels in patients with heart failure (HF).</p><p><b>METHODS</b>113 patients with HF were enrolled. There were 68 patients with ischaemic heart disease (IHD) and 22 with overt HF. Cardiac scintigraphy was performed 7 ± 3 days after admission, and heart-to-mediastinum (H/M) count ratios on early and delayed images and washout rates (WR) of ¹²³I-BMIPP were recorded. Serum BNP levels were recorded on the day of ¹²³I-BMIPP imaging. The ejection fraction (EF) was calculated just before cardiac scintigraphy using conventional echocardiography.</p><p><b>RESULTS</b>The mean BNP level and EF were 282 pg/mL and 47%, respectively, with significant correlation between them. The mean H/M count ratios on early and delayed images were 2.29 and 1.93, respectively, showing significant positive correlations with EF (r = 0.31, p = 0.0006). The WR was significantly correlated with EF (r = -0.36, p < 0.0001) and BNP levels (r = 0.33, p = 0.003), and mean WR was significantly higher in patients with overt HF compared to those without (p < 0.001). Patients with IHD had significantly higher EFs than those with non-IHD (p = 0.03).</p><p><b>CONCLUSION</b>The evaluation of impaired myocardial metabolism using ¹²³I-BMIPP scintigraphy and serum BNP levels appears to be useful for the evaluation of severity of HF.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Time Factors / Blood / Diagnostic Imaging / Echocardiography / Biomarkers / Treatment Outcome / Natriuretic Peptide, Brain / Diagnosis / Myocardial Perfusion Imaging Type of study: Diagnostic study Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Singapore medical journal Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Time Factors / Blood / Diagnostic Imaging / Echocardiography / Biomarkers / Treatment Outcome / Natriuretic Peptide, Brain / Diagnosis / Myocardial Perfusion Imaging Type of study: Diagnostic study Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male Language: English Journal: Singapore medical journal Year: 2012 Type: Article