Relation between the angiotensin II type 2 receptor polymorphism and essential hypertension in men / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 592-594, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-334651
ABSTRACT
<p><b>OBJECTIVE</b>To identify single nucleotide polymorphisms (SNP) of the angiotensin II type 2 receptor (AGTR2) gene, and to determine whether the AGTR2 polymorphisms are associated with essential hypertension in a male Chinese population.</p><p><b>METHODS</b>Direct DNA sequencing was performed in 20 subjects. 96 male hypertensive patients and 107 normal controls were included to assess the contribution of the SNP of AGTR2 gene to hypertension.</p><p><b>RESULTS</b>Seven SNP of the AGTR2 gene were identified, of which 4 were reported for the first time. A case-control study including two polymorphisms (A1675G and T1334C) showed a significant increase in the A1675 allele frequency among male hypertensive subjects as compared with normotensive subjects (49.0% vs 34.6%, P < 0.05).</p><p><b>CONCLUSION</b>The AGTR2 A1675G polymorphism might be involved in the development of essential hypertension in male Chinese.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Single Nucleotide
/
Receptor, Angiotensin, Type 2
/
Asian People
/
Gene Frequency
/
Genetics
/
Hypertension
Type of study:
Observational study
/
Risk factors
Limits:
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2005
Type:
Article
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