The significance of Th1/Th2 function imbalance in patients with post-infarction cardiac insufficiency / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 526-528, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-334667
ABSTRACT
<p><b>OBJECTIVE</b>To study the significance of Th1/Th2 function imbalance in patients with post-infarction cardiac insufficiency.</p><p><b>METHODS</b>Forty-three MI (myocardial infarction) patients were divided into 2 groups one month after the onset according to the New York Heart Association (NYHA) classification system group MI 1 (I, II) 25 patients and group MI 2 (III, IV) 18 patients. At the same time, the heart function was evaluated by two-dimensional echocardiography. Peripheral blood mononuclear cells (PBMCs) were collected from these patients. Cytokine-producing CD4 + T cells were quantified by 3-color flow cytometry after being stimulated with phorbol myristate acetate (PMA) and ionomycin. After being stimulated with PHA, the levels of IFN-gamma and IL-4 in culture supernatants were measured by ELISA.</p><p><b>RESULTS</b>The frequencies of IFN-gamma-producing T cells were found to be significantly higher in group MI 2 (16.8%) than that in group MI 1 (13.1%). There was no significant difference on the frequencies of IL-4-producing peripheral T cells between the two groups. The IFN-gamma level and the ratios of IFN-gamma/IL-4 in group MI 2 were significantly higher than those in group MI 1, while there was no significant difference in IL-4 levels between the two groups.</p><p><b>CONCLUSIONS</b>The Th-cell function was associated with heart function in post MI patients. The up-regulation of Th1 cell function was consistent with poor heart function, suggesting that Th1/Th2 cell function imbalance may participate in ventricular remodelling after MI.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
CD4-Positive T-Lymphocytes
/
Interleukin-4
/
Interferon-gamma
/
Th2 Cells
/
Th1 Cells
/
Allergy and Immunology
/
Heart Failure
/
Metabolism
/
Myocardial Infarction
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2005
Type:
Article
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