The relationship between expressions of beta1-, beta2-, beta3-adrenoceptor mRNA of myocardium and cardiac function in patients with heart failure / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 351-353, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-334703
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the alteration of expressions of beta(1)-, beta(2)-, beta(3)-adrenoceptor mRNA in human myocardial tissue and the relation between their expressions and cardiac function in patient with heart failure.</p><p><b>METHODS</b>The mRNA expressions of beta(1)-, beta(2)- and beta(3)-adrenergic receptors in myocardial tissue were analyzed by using the reverse transcriptase-polymerase chain reaction in 24 patients with heart failure of valvular heart disease and 5 control subjects.</p><p><b>RESULTS</b>Beta(1)-adrenergic receptor mRNA expressions in myocardium were significantly lower in patients with heart failure than those in control subjects, and progressively reduced with aggravation of heart function. By contrast, beta(3)-adrenoceptor mRNA expressions were significantly higher in patients with heart failure than those in controls, and progressively elevated with aggravation of cardiac function. No difference was observed in beta(2)-adrenergic receptor among all groups.</p><p><b>CONCLUSION</b>The changes of beta-adrenergic receptor mRNA expression are associated with the severity of heart failure.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Case-Control Studies
/
Receptors, Adrenergic, beta-2
/
Receptors, Adrenergic, beta-1
/
Receptors, Adrenergic, beta-3
/
Genetics
/
Heart Failure
/
Metabolism
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2005
Type:
Article
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