Molecular interaction between PrP protein and the signal protein 14-3-3 beta / 病毒学报
Chinese Journal of Virology
;
(6): 208-212, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-334749
ABSTRACT
The molecular interaction between PrP and 14-3-3 beta and the possible interactional domain between two proteins were studied by co-immunoprecipitation, pull down and FRET assays. The results showed that PrP protein could interact with 14-3-3 beta in vitro and in vivo. The domain which responded for the interaction was located at C-terminal of PrP (amino acid residues 106 to 126). This study of the interaction between PrP and 14-3-3 protein further provided the insight into the potential role of 14-3-3 in the biological function of PrP and the pathogenesis of prion disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Binding
/
Brain
/
Prions
/
HeLa Cells
/
Fluorescence Resonance Energy Transfer
/
14-3-3 Proteins
/
Immunoprecipitation
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2009
Type:
Article
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