Evaluation of the protection conferred by several avian infectious bronchitis attenuated vaccines against the field strain CK/CH/LDL/97 I in China / 病毒学报
Chinese Journal of Virology
;
(6): 111-116, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-334831
ABSTRACT
The entire S1 protein gene of five infectious bronchitis (IB) vaccine strains (JAAS, IBN, Jilin, J9, H120) used in China were compared with that of the IB field isolate CK/CH/LDL/97 I present in China. The nucleotide and deduced amino acid similarities between the five IB vaccine strains and the field strain, CK/CH/LDL/97 I, were not more than 76.4% and 78.7%, respectively. Phylogenetic analysis based on the S1 gene showed that the vaccine strains and the field strain belonged to different clusters and had larger evolutionary distances, indicating that they were of different genotypes. The five vaccine strains were used for protection test against challenge of the field isolate CK/CH/LDL/97 I. The chickens inoculated with five vaccine strains showed morbidity as high as 30%-100% after challenged with the CK/CH/ LDL/97 I strain. The organ samples at 5 days post challenge showed that the viral detection rates were 50%-90% and 10%-30% for trachea and kidney, respectively. The live attenuated vaccines only provided partial protection to the vaccinated chickens against heterologous IBV infection, CK/CH/LDL/97 I.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Poultry Diseases
/
Virology
/
Blood
/
Membrane Glycoproteins
/
Vaccines, Attenuated
/
Viral Vaccines
/
Chickens
/
Viral Envelope Proteins
/
Classification
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2008
Type:
Article
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