Application of mycophenolate mofetil in hepatitis C patients after kidney transplantation / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1215-1221, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-334955
ABSTRACT
<p><b>OBJECTIVE</b>To discuss adequate application of mycophenolate mofetil (MMF) in hepatitis C patients after kidney transplantation.</p><p><b>METHOD</b>A one-year follow-up study was conducted in 49 patients with hepatitis C but normal liver function before kidney transplantation, who were given postoperatively immunosuppressants of predisone, MMF and CsA/FK506. Patients with abnormal liver function after kidney transplantation who continued MMF therapy at routine dose and those with reduced or suspended MMF therapy all received intravenous therapy for liver protection, and the duration of therapies was recorded.</p><p><b>RESULTS</b>Nineteen patients presented with abnormal liver function after operation, and the duration of abnormal liver function till recovery was 32.82-/+4.13 days in the patients with unsuspended MMF therapy and 13.31-/+2.98 days in those with reduced or suspended MMF (P<0.05); the former patients required subsequently 62.7-/+3.23 days to recover normal liver function and the latter need only 23.4-/+2.29 days (P<0.05).</p><p><b>CONCLUSION</b>MMF should be reduced or suspended when liver function abnormality occurred in patients with hepatitis C after kidney transplantation, and immediate intravenous therapy for liver protection may prove beneficial.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Period
/
General Surgery
/
Uremia
/
Follow-Up Studies
/
Kidney Transplantation
/
Hepatitis C
/
Therapeutic Uses
/
Drug Therapy
/
Immunosuppressive Agents
/
Liver Function Tests
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2006
Type:
Article
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