Diagnostic value of serum islet autoantibody in hepatogenic diabetes mellitus / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1034-1036, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-334999
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the diagnostic value of serum islet autoantibody-glutamic acid decarboxylase antibody (GADA) and islet cell antibody (ICA) in patients with hepatogenic diabetes.</p><p><b>METHODS</b>Serum GADA and ICA were measured with enzyme-linked immunosorbent assay (ELISA) in 217 patients with chronic hepatitis B (CH) or liver cirrhosis (LC). The positivity rate of GADA and ICA in different phases of CH and LC and their relations with diabetes mellitus were analyzed.</p><p><b>RESULTS</b>The positivity rate of the islet autoantibody in the circulation was 72% in CH and LC patients with diabetes mellitus and 30% in patients with normal glucose level, showing significant difference between the two patient groups (Chi2=36.620, P=0.000). CH patients with diabetes had much higher positivity rate for the antibody [52% than type 2 diabetic patients with liver dysfunction [8%, P<0.05]. The positivity rate was also much higher in CH and LC patients with lowered C peptide level [70%] than in those with normal C peptide level [40%, P<0.005].</p><p><b>CONCLUSION</b>Both GADA and ICA have important value in the diagnosis of hepatogenic diabetes and may serve as indexed in laboratory test for distinguishing hepatogenic diabetes from type 2 diabetes.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
Blood
/
Predictive Value of Tests
/
Islets of Langerhans
/
Hepatitis B, Chronic
/
Diabetes Mellitus, Type 1
/
Diabetes Mellitus, Type 2
/
Diagnosis
/
Diagnosis, Differential
/
Allergy and Immunology
Type of study:
Diagnostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2006
Type:
Article
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