Mutations of mitochondrial tRNAand their connection with hearing loss / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 128-132, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-335167
ABSTRACT
Mitochondrial tRNAgene mutation is closely related to acoustic nerve deafness. Some mutations can affect the structure and transcriptional processing of tRNA, for instance m.7444G>A mutation in tRNAprecursor 3' side, m.7472 insC as well as m.7511T>C mutations in the stem and ring of tRNA, may influence tRNAstability, thus affect the synthesis of mitochondrial peptides, reduce the production of ATP and cause deafness. This article focuses on mitochondrial tRNAgene mutations as well as the mechanism underlying hearing loss.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA
/
RNA, Transfer, Ser
/
Base Sequence
/
Chemistry
/
Amino Acid Sequence
/
Genetic Predisposition to Disease
/
Mitochondrial Proteins
/
Genetics
/
Hearing Loss
/
Mutation
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2017
Type:
Article
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