Estrogen receptor expression in adrenocortical carcinoma / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 1-6, 2009.
Article
in English
| WPRIM
| ID: wpr-335408
ABSTRACT
<p><b>OBJECTIVE</b>Adrenocortical carcinoma (ACC) is a rare but highly malignant tumor, and its diagnosis is mostly delayed and prognosis is poor. We report estrogen receptor (ER) expression in this tumor and our clinical experiences with 17 ACC cases.</p><p><b>METHODS</b>The data of the 17 patients (9 females and 8 males, age range from 16 to 69 years, mean age of 42.6 years) with ACC were reviewed, and symptoms, diagnostic procedures, treatment, and results of follow-up were evaluated. Immunohistochemistry was used to detect ER expression in tumor samples from the 17 patients.</p><p><b>RESULTS</b>At the time of diagnosis, 4 tumors were classified as Stage I, 4 as Stage II, 3 as Stage III, and 6 as Stage IV. Eight patients demonstrated positive nuclear immunostaining of ER. The prognosis of patients with ER positive was significantly better (P<0.05) than that of patients with ER negative, with 1- and 5-year survival rates at 86% and 60% for ER-positive patients, and 38% and 0% for ER-negative patients, respectively.</p><p><b>CONCLUSION</b>ER-positivity may be one of the factors associated with a worse prognosis of ACC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Receptors, Estrogen
/
Biomarkers, Tumor
/
Survival Analysis
/
China
/
Incidence
/
Survival Rate
/
Risk Factors
/
Mortality
/
Adrenal Cortex Neoplasms
/
Adrenocortical Carcinoma
Type of study:
Diagnostic study
/
Etiology study
/
Incidence study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2009
Type:
Article
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