Association between Nef-specific CD8 T-cell responses and disease progression in HIV-1 subtype B infection / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1609-1615, 2006.
Article
in English
| WPRIM
| ID: wpr-335559
ABSTRACT
<p><b>BACKGROUND</b>The correlation between HIV-1 Nef-specific CD8 T-cell responses and markers of HIV-1 disease progression still remains unclear. This study analysed and compared the role of HIV-1 Nef-specific CD8 T-cell responses in patients with different disease status.</p><p><b>METHODS</b>Two groups of patients with HIV-1 subtype B infection were selected according to CD4 count and clinical manifestations long-term nonprogressors (LTNPs, n = 20) and advanced progressors (APs, CD4 count < 500 cells/microl, n = 34). Nef-specific CD8 T-cell responses were studied by interferon-gamma ELISpot assay against 3 pools of HIV-Nef peptides.</p><p><b>RESULTS</b>Nef-specific CD8 T-cell responses did not correlate with viral load or CD4 count in all patients and no significant differences were found in the magnitude of Nef-specific CD8 T-cell responses between groups LTNPs and APs (670 SFC/10(6) peripheral blood mononuclear cells vs 1107 SFC/10(6) peripheral blood mononuclear cells, P = 0.255). Further comparisons showed that there were also no significant correlations observed in group LTNPs, but Nef-specific CD8 T cells correlated negatively with viral load (r = -0.397, P = 0.020) and positively with CD4 count (r = 0.364, P = 0.034) in group APs.</p><p><b>CONCLUSION</b>These data suggest that different correlation patterns between Nef-specific CD8 T-cell responses and disease progression exist in LTNPs and APs. Although a negative association was observed with concurrent plasma HIV RNA in APs, Nef-specific CD8 T-cell responses might fail to play a protective role in different stages of HIV-1 infection.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
RNA, Viral
/
Gene Products, nef
/
Acquired Immunodeficiency Syndrome
/
HIV-1
/
Classification
/
Disease Progression
/
CD8-Positive T-Lymphocytes
/
CD4 Lymphocyte Count
/
Allergy and Immunology
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2006
Type:
Article
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