Serum Gamma-glutamyl Transferase Concentration Within the Reference Range is Related to the Coronary Heart Disease Risk Prediction in Korean Men: Analysis of the Korea National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011) / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2006-2011, 2015.
Article
in English
| WPRIM
| ID: wpr-335668
ABSTRACT
<p><b>BACKGROUND</b>Limited data exist on the association of serum gamma-glutamyl transferase (GGT) level within the reference range with the increased risk of coronary heart disease (CHD) prediction in men. The study examined the association between serum GGT concentration within the reference range and the CHD risk prediction in Korean men.</p><p><b>METHODS</b>The study employed data from Korean National Health and Nutrition Examination Survey (V-1, 2010 and V-2, 2011) where a total of 1301 individuals were analyzed. A 10-year CHD risk prediction was computed using the Framingham Risk Score (FRS) modified by the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III).</p><p><b>RESULTS</b>Positive correlations were established between log-transformed GGT concentration and FRS (r = 0.237, P < 0.001). After adjustment of body mass index, the amount of alcohol intake and low-density lipoprotein-cholesterol, the odds ratio (95% confidence interval) for intermediate risk and beyond of 10-year CHD prediction (10-year risk ≥10%) with lowest quartile of participants was 1.21 (0.78-1.87) for second quartiles, 1.39 (0.88-2.21) for third quartiles and 2.03 (1.23-3.34) for highest quartiles.</p><p><b>CONCLUSIONS</b>Higher serum GGT within its reference range was significantly correlated with a 10-year CHD risk prediction estimation using NCEP ATP III in Korean men.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reference Values
/
Blood
/
Nutrition Surveys
/
Risk Factors
/
Coronary Disease
/
Asian People
/
Diagnosis
/
Gamma-Glutamyltransferase
/
Metabolism
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2015
Type:
Article
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