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ApaI, BsmI, FokI, and TaqI Polymorphisms in the Vitamin D Receptor Gene and Parkinson's Disease / 中华医学杂志(英文版)
Chinese Medical Journal ; (24): 1809-1814, 2015.
Article in English | WPRIM | ID: wpr-335705
ABSTRACT
<p><b>BACKGROUND</b>The vitamin D receptor (VDR) gene has been identified as a candidate gene for susceptibility to Parkinson's disease (PD), but results from genetic association studies to date are inconsistent. Here, we conducted a meta-analysis of published case-control studies to evaluate the association of the extensively studied VDR ApaI (G/T), BsmI (G/A), FokI (C/T), and TaqI (T/C) gene polymorphisms with risk of PD.</p><p><b>METHODS</b>Electronic search at PubMed, EMBASE, EBSCO, China National Knowledge Infrastructure, Weipu database, and Wanfang database was conducted to identify all relevant studies. Odds ratio (OR) with 95% confidence interval (CI) values was applied to evaluate the strength of the association.</p><p><b>RESULTS</b>A total of seven studies with 2034 PD cases and 2432 controls were included in the meta-analysis following the inclusion and exclusion criteria. Overall, no significant association between ApaI, BsmI, and TaqI gene polymorphisms and PD susceptibility in all four genetic models was found (T vs. G OR = 1.00, 95% CI 0.89-1.12, P = 0.97; A vs. G OR = 0.94, 95% CI 0.77-1.15, P = 0.53; C vs. T OR = 1.03, 95% CI 0.85-1.25, P = 0.77) while a significant association between FokI (C/T) and PD risk was observed (C vs. T OR = 1.41, 95% CI 1.14-1.75, P = 0.001; CC vs. TT OR = 2.45, 95% CI 1.52-3.93, P = 0.0002; CT vs. TT OR = 2.21, 95% CI 1.38-3.52, P = 0.0009, CC vs. CT+TT OR = 2.32, 95% CI 1.49-3.61, P = 0.0002).</p><p><b>CONCLUSIONS</b>Polymorphisms of ApaI, BsmI, and TaqI may not be associated with the susceptibility to PD while the FokI (C/T) polymorphism is possibly associated with increased PD risk. However, conclusions should be cautiously interpreted due to the relatively small number of studies included.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Parkinson Disease / Polymorphism, Genetic / Receptors, Calcitriol / Genetic Predisposition to Disease / Genetics Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Chinese Medical Journal Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Parkinson Disease / Polymorphism, Genetic / Receptors, Calcitriol / Genetic Predisposition to Disease / Genetics Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Chinese Medical Journal Year: 2015 Type: Article